📰 Detect TB directly by sampling exhaled air

The World Health Organization (WHO) estimates the number of new TB cases at 10 million per year, of which 12% are children. However, 1/3 of these cases will go undiagnosed, especially due to the low efficiency of currently available tools. In a study published in the journal NatureCommunicationsscientists show thatweather (Air is a mixture of gases that make up the Earth’s atmosphere. Odorless and…) contains exhalation by tuberculosis patients tracks (TRACES (Trade Control and Expert System) is a veterinary health network…) the presence of bacteria responsible for tuberculosis (Tuberculosis is a contagious, non-immunizable, infectious disease with symptoms…) and its analysis a diagnostic (Diagnosis (from Greek δι?γνωσα, diagnosi, from…) more responsive, quick and easy disease (A disease is a change in the functions or health of a living organism, animal…).


Image: Tuberculosis patients inhale large amounts of molecules produced by Mycobacterium tuberculosis, including lipids, glycoconjugates and proteins, which can be detected to diagnose the disease.
© Jérôme Nigou, Olivier Neyrolles (created with BioRender.com)

WHO aims to reduce TB mortality and morbidity by 90% and 80%, respectively, by 2030 compared to 2015. point (graphic) more effective diagnostic tools. The diagnosis of tuberculosis is currently based on clinical and radiographic examinations, as well as bacteriological analysis of sputum (sputum). Mycobacterium tuberculosisthe bacterium responsible for the disease is sought by microscopic analysis, culture (The UNESCO definition of culture is as follows [1] 🙂 or reinforcement (We’re talking about a power amp for a range of systems that power up…) gen. However, sputum analysis has low sensitivity in children and individuals who shed few bacteria, such as HIV-infected patients.

In this study, scientists investigated the diagnostic potential of a fluid (A liquid is a perfectly deformable material medium. We group under it…) a relatively little-studied biological, exhaled air condensate. Corresponding to this fluid phase (The word phase can have several meanings, it is used in several fields and…) fluid (The liquid phase is the state of matter. Matter in this form…) air sample taken out by condensation (Condensation is the name given to the physical phenomenon related to the change of state of matter that…) hour cold (Cold is the opposite of heat associated with low temperatures.)has many advantages Context (The context of the event includes the circumstances and conditions surrounding it;…) tuberculosis diagnosis, infectious disease (An infectious disease is a disease caused by an infection.) lungs (Lungs are plants belonging to the Boraginaceae family.). Indeed, it consists of aerosolization of the fluid surrounding the respiratory epithelium; therefore, its composition varies according to the pathological condition lungs (The lung is an invaginal organ that allows the exchange of vital gases, especially…). In addition, it is easy to collect, non-invasive and does not require specialized personnel.

Thus, scientists were able to detect the presence of molecules (sugars, lipids and proteins) produced by them in the condensate of the air extracted from tuberculosis patients. M. tuberculosisand allows these patients to be distinguished from healthy individuals or those suffering from other respiratory tract infections without any ambiguity. Interestingly, this approach can be transferred directly to bed in a short period of time sick (In medicine, the term patient usually refers to a person receiving…)Bacteriological analysis of sputum allows detecting negative tuberculosis patients.

This ongoing pilot study with larger international patient cohorts thus opens a new diagnostic pathway that may improve patient management. to fill (Cargo means what it really is…) patients and reduces the incidence of tuberculosis.

To know more:
THERE IS Mycobacterium tuberculosis A fingerprint on a person’s breath makes it possible to detect tuberculosis.
Sergio Fabian Mosquera-Restrepo, Sophie Zuberogoïtia, Lucie Gouxette, Emilie Layre, Martine Gilleron, Alexandre Stella, David Rengel, Odile Burlet-Schiltz, Ana Cecilia Caro, Luis F. Garcia, César Segura, Carlosál Rojaélome Nigou.
Nature Communications 13, 7751 (2022) DOI: https://doi.org/10.1038/s41467-022-35453-5

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